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Case Study · Pakistan

Aqua Pure: A Sterile IV Fluid Facility, Planned End to End

Feasibility planning for a plastic-bottle IV manufacturing facility, bringing production, utilities, cleanrooms and engineering into one coordinated plant concept.

Sterile IV Manufacturing Plant Engineering Cleanroom & HVAC Feasibility Planning
Project Aqua Pure
Location Pakistan
Project Stage Feasibility & Budget Proposal · 2026
Design Basis 24,000 Bottles / Hour
01 · Project Overview

Planning the Complete Facility Before Major Investment

The Aqua Pure project demonstrates how Hawkland structures a sterile IV manufacturing facility at the feasibility stage, allowing key technical and layout decisions to be evaluated before construction or procurement begins.

A new sterile IV production facility

A pharmaceutical group in Pakistan wanted to plan a facility for large-volume IV fluids in plastic bottles. Before committing capital, the plant needed to be sized, organised and evaluated against GMP expectations.

Two master plans, one complete project view

Hawkland's feasibility proposal compared an expanded plant layout designed for future production lines with a compact two-storey alternative that reduces land use while increasing finished-goods capacity.

GMP-oriented planning from the beginning

The proposal was developed around EU Annex 1, WHO TRS 1044 principles and Pakistan DRAP GMP requirements, integrating production, utilities, personnel flow and controlled cleanroom environments.

02 · Project Scope

What Was Included in the Planning

The study combines the manufacturing line and the supporting facility infrastructure instead of treating each system as an isolated package.

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Two Master Plan Options

Expanded and compact layouts were compared for the same project site.

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IV Production Line Concept

Injection stretch blow molding and blow-fill-seal technologies were incorporated into the feasibility study.

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Terminal Sterilisation

Sterilisation planning was integrated with automated product inspection.

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Water for Injection

WFI generation, storage and distribution were included in the utility planning.

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Grade B, C & D Cleanrooms

Controlled areas were organised using a defined cleanroom zoning and pressure-cascade strategy.

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Personnel Flow

Step-by-step personnel gowning and movement were considered within the proposed layout.

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Equipment & Engineering

Equipment lists, engineering drawings and an unpriced bill of quantities supported the feasibility proposal.

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Project Delivery Framework

URS development, equipment selection, commissioning, validation, training and after-sales support form the wider Hawkland delivery methodology.

03 · Production Concept

How the Proposed Plant Is Organised

The feasibility concept creates a logical route from pharmaceutical water and raw materials through sterile production and final packaging.

Water &
Raw Materials
Compounding
Grade C
Container
Forming
Filling
Grade B
Terminal
Sterilisation
Automated
Inspection
Labeling &
Packing
Finished
Goods
04 · Controlled Environment

Cleanroom Zoning & Pressure Cascade

The proposal separates production activities into controlled zones and establishes increasing positive pressure toward the most critical sterile areas.

Zone
Primary Use
Relative Pressure
Grade B
Filling & autoclave inlet
Highest · +45 Pa
Grade C
Compounding & dispensing
+30 Pa
Grade D
Packaging & autoclave outlet
+15 Pa
Unclassified
Corridors & warehouse
Reference · 0 Pa
05 · Hawkland Methodology

From Requirement to Operational Support

Hawkland structures IV projects through a defined sequence, connecting technical planning with equipment, validation and long-term support.

01 Requirements
02 Design & Engineering
03 Equipment & Supply
04 Install & Commission
05 Validation
06 Training & Support
06 · Why It Matters

A Practical Planning Model for Local IV Manufacturing

The same early-stage questions apply to pharmaceutical manufacturers planning IV production across Africa: capacity, layout, GMP requirements, skills and long-term scalability.

Local IV Production

Establish a defined technical route for producing IV fluids locally.

Right-Sized Plants

Compare facility layouts against real production and volume requirements.

GMP-Oriented Design

Plan cleanrooms, utilities and qualification before construction begins.

Skilled Local Teams

Build training and technology transfer into the project scope.

Long-Term Support

Create room for expansion and technical support beyond commissioning.

Planning an IV / LVP Project?

Turn Early-Stage Planning Into a Buildable Facility

Hawkland Global supports pharmaceutical manufacturers from feasibility and technical planning through equipment integration, commissioning, validation and training.

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